Understanding how certain enzymes reverse specific protein modifications.
Reversal of residue-specicific ADP-ribosylations by ADP-ribosyl-acceptor hydrolases
This study is looking at how certain enzymes can help fix important changes in proteins that affect things like DNA repair and cell death, which could help us understand how our cells stay healthy and function properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11216886 on NIH RePORTER |
What this research studies
This research investigates the role of ADP-ribosyl-acceptor hydrolases (ARHs) in reversing specific protein modifications that are crucial for various biological processes, including DNA repair and cell death. By developing sensitive assays, the research aims to measure how these enzymes selectively reverse modifications at specific sites on proteins. This could lead to a better understanding of how these processes maintain genomic integrity and influence cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to DNA damage or cellular regulation.
Not a fit: Patients with conditions unrelated to DNA damage responses or protein modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to DNA damage and cellular dysfunction.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding protein modifications and their implications in cellular processes.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kim, in-Kwon — University of Pittsburgh at Pittsburgh
- Study coordinator: Kim, in-Kwon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.