Understanding how certain enzymes regulate reactive oxygen species in cells
Molecular Mechanisms Underlying Mammalian NADPH Oxidase Activation and Regulation
This study is looking at how certain enzymes that create reactive oxygen species (ROS) affect our cells' health, and it aims to find new ways to treat diseases like cancer and heart disease that are related to these harmful substances, so patients can eventually benefit from better-targeted therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11030781 on NIH RePORTER |
What this research studies
This research investigates the role of NADPH oxidases, enzymes that produce reactive oxygen species (ROS), in maintaining cellular health. By using advanced techniques like cryo-electron microscopy, the study aims to uncover the molecular mechanisms that activate and regulate these enzymes. Understanding these processes could help in developing new treatments for diseases linked to oxidative stress, such as cancer and heart disease. Patients may benefit from insights that could lead to targeted therapies for conditions exacerbated by ROS imbalance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic conditions like cancer, cardiac disorders, or neurodegenerative diseases linked to oxidative stress.
Not a fit: Patients with acute conditions unrelated to oxidative stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with oxidative stress.
How similar studies have performed: Previous research has shown promising results in targeting NADPH oxidases for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Lee, Chia-Hsueh — St. Jude Children's Research Hospital
- Study coordinator: Lee, Chia-Hsueh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.