Understanding how certain enzymes interact with lipids to fight COVID-19
Official title: The biochemical mechanism and pharmacological inhibition of phosphatidylinositol phosphate kinases
Funded at Yale University · NIH-10896431 · Data updated 2026-11-12
This study is looking at certain enzymes that help break down fats in our bodies and how they might be linked to the virus that causes COVID-19, with the hope of finding new ways to treat the illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $334,149 |
| NIH project number | 5R01GM150502-02 |
| Project ID | NIH-10896431 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by COVID-19 or those at high risk of severe illness from the virus.
✕Less likely to help
Patients who are not infected with COVID-19 or who have already recovered from the virus may not benefit from this research.
What this research studies
This research investigates the biochemical mechanisms of specific enzymes called phosphatidylinositol phosphate kinases, which play a crucial role in lipid metabolism. By examining how these enzymes bind to their lipid substrates, the study aims to uncover their catalytic specificity and how they can be inhibited. The research includes laboratory techniques such as crystallization and genetic experiments to explore the role of these enzymes in the life cycle of the SARS-CoV-2 virus, which causes COVID-19. If successful, this research could lead to new therapeutic strategies for treating COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for COVID-19 by targeting specific enzymes involved in the virus's life cycle.
How similar studies have gone: Other research has shown promise in targeting similar biochemical pathways for therapeutic interventions, indicating potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Ha, Ya — Yale University
- Study coordinator: Ha, Ya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.