Understanding how certain enzymes interact with carbon gases
Official title: Biomimetic Reactivity and Spectroscopy of Carbon Monoxide Dehydrogenase C-Clusters
Funded at Yale University · NIH-11218662 · Data updated 2026-11-12
This study is looking at how certain enzymes help break down gases like carbon dioxide and carbon monoxide, which could help us learn more about creating energy and using natural materials better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 5F32GM150246-02 |
| Project ID | NIH-11218662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biochemical processes related to carbon management and energy production, particularly those with a background in biochemistry or environmental science.
✕Less likely to help
Patients with conditions unrelated to biochemical processes or those not engaged in scientific research may not benefit from this research.
What this research studies
This research investigates the biochemical processes involving carbon-containing gases like carbon dioxide and carbon monoxide, focusing on how specific enzymes called Carbon Monoxide Dehydrogenases (CODHes) function in these reactions. By using advanced techniques such as spectroscopy and crystallography, the study aims to uncover the structure and mechanism of the enzyme's active site, known as the C-cluster. The research also explores synthetic models to better understand the electronic structure and reactivity of these metalloenzymes, which could lead to insights into energy generation and biomass synthesis.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of enzyme functions that are crucial for energy production and carbon management, potentially leading to innovative solutions for environmental challenges.
How similar studies have gone: While the specific approach of this research is novel, similar studies in bioinorganic chemistry have shown promise in understanding enzyme mechanisms and could provide valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Stonebraker, Samuel Newman — Yale University
- Study coordinator: Stonebraker, Samuel Newman
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.