Understanding how certain enzymes help maintain protein balance during stress and aging
Official title: Function of SMYD lysine methyltransferases in stress responses and proteostasis
Funded at University of Maryland Baltimore County · NIH-10904928 · Data updated 2026-11-12
This study is looking at how certain enzymes help keep our cells healthy by managing proteins, especially when we're stressed or getting older, which could help us understand diseases related to aging and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore County NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $309,806 |
| NIH project number | 5R01GM148698-02 |
| Project ID | NIH-10904928 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related conditions or diseases linked to protein misfolding.
✕Less likely to help
Patients with acute, non-aging related conditions may not benefit from this research.
What this research studies
This research investigates the role of SMYD lysine methyltransferases in maintaining protein homeostasis, particularly during stress and aging. It focuses on how these enzymes regulate proteins that are crucial for proper cellular function and prevent the accumulation of misfolded proteins. By studying a specific enzyme from yeast, the research aims to uncover its regulatory mechanisms and how it contributes to the overall health of cells. This could lead to insights into aging-related diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating aging-related diseases by improving protein balance in cells.
How similar studies have gone: Previous research has shown that targeting protein homeostasis can be effective in treating certain aging-related diseases, suggesting a promising avenue for this approach.
Where this research is happening
-
University of Maryland Baltimore County
Baltimore, United States Active
Researchers
- Principal investigator: Green, Erin — University of Maryland Baltimore County
- Study coordinator: Green, Erin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.