Understanding how certain enzymes help bacteria resist antibiotics
Mechanistic basis of how LD-transpeptidases protect against outer membranedefects
['FUNDING_R01'] · UNIVERSITY OF TEXAS DALLAS · NIH-11035174
This study is looking at how certain enzymes help the bacteria Acinetobacter baumannii survive antibiotics, with the goal of finding new ways to fight infections for patients dealing with this tough bug.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS DALLAS (nih funded) |
| Locations | 1 site (RICHARDSON, UNITED STATES) |
| Trial ID | NIH-11035174 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which LD-transpeptidases enable the bacteria Acinetobacter baumannii to survive despite antibiotic treatment. By exploring how these enzymes modify the bacterial cell envelope, the study aims to uncover new strategies to combat antibiotic resistance. The research will involve laboratory experiments to analyze the function and regulation of these enzymes in the context of antibiotic-resistant infections. Patients with infections caused by A. baumannii may benefit from the insights gained through this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with infections caused by Acinetobacter baumannii, particularly those with multidrug-resistant strains.
Not a fit: Patients with infections caused by bacteria other than Acinetobacter baumannii may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from antibiotic-resistant infections.
How similar studies have performed: Previous research has shown promise in understanding antibiotic resistance mechanisms, but this specific approach focusing on LD-transpeptidases is relatively novel.
Where this research is happening
RICHARDSON, UNITED STATES
- UNIVERSITY OF TEXAS DALLAS — RICHARDSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOLL, JOSEPH MICHAEL — UNIVERSITY OF TEXAS DALLAS
- Study coordinator: BOLL, JOSEPH MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.