Understanding how certain enzymes form specific chemical bonds
Official title: Characterization of metal cofactors involved in GDGT-MAS Csp3-Csp3 bond formation
Funded at Pennsylvania State University, the · NIH-11070718 · Data updated 2026-11-12
This study is looking at how a special enzyme helps create strong connections between carbon atoms, which could lead to better ways to deliver medications to patients by improving the stability of cell membranes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32GM157879-01 |
| Project ID | NIH-11070718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions requiring advanced drug delivery methods or those involved in studies of lipid metabolism.
✕Less likely to help
Patients with conditions unrelated to lipid metabolism or those not requiring innovative drug delivery systems may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which specific enzymes, particularly those from the radical S-adenosylmethionine (RS) enzyme superfamily, facilitate the formation of Csp3-Csp3 bonds between inert carbon atoms. The study focuses on a newly identified enzyme, GDGT-MAS, which catalyzes the formation of macrocyclic lipids that enhance the stability of cellular membranes. By exploring the role of metal cofactors in this process, the research aims to uncover new biochemical pathways that could lead to innovative applications in drug delivery systems. Patients may benefit from advancements in drug formulations that utilize these findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective drug delivery systems that enhance the stability and efficacy of medications.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding enzyme mechanisms and their applications in biotechnology.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Mbeuh Lahom Lot, Tamra Carlicia — Pennsylvania State University, the
- Study coordinator: Mbeuh Lahom Lot, Tamra Carlicia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.