Understanding how certain enzymes control cell functions and responses to stress
Regulation of PPM family serine/threonine phosphatases
This study is looking at special enzymes that help control how cells make decisions, which is important for understanding diseases like cancer and inflammation, and it could help find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-11090818 on NIH RePORTER |
What this research studies
This research investigates the regulation of PPM family serine/threonine phosphatases, which are enzymes that play a crucial role in controlling cell fate decisions through reversible protein phosphorylation. By studying these phosphatases, particularly in bacteria, the research aims to uncover how they are directed to specific substrates and regulated, which is essential for understanding their role in diseases. The findings could lead to new therapeutic targets for conditions where these processes are dysregulated, such as cancers and inflammatory diseases. The approach combines molecular biology techniques with insights from bacterial physiology to draw parallels with human signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cancers or inflammatory diseases linked to cell signaling dysregulation.
Not a fit: Patients with conditions unrelated to cell signaling or those not affected by dysregulated phosphatase activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by dysregulated cell signaling, including various cancers.
How similar studies have performed: Other research has shown success in targeting similar phosphatase pathways for therapeutic development, indicating a promising avenue for this approach.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Bradshaw, Niels Raab — Brandeis University
- Study coordinator: Bradshaw, Niels Raab
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.