Understanding how certain enzymes contribute to cancer
A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
This project aims to discover which specific proteins are affected by certain enzymes called tyrosine phosphatases, which play a role in many cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11146612 on NIH RePORTER |
What this research studies
Our bodies use enzymes called tyrosine phosphatases to control important cell signals, and when these enzymes don't work right, it can lead to cancers. While we know many enzymes that add signals, we don't fully understand which specific proteins these phosphatases remove signals from. This project is developing a new method that combines protein engineering with advanced analysis to identify these specific protein partners in living cells. By understanding these interactions, we hope to uncover how these enzymes contribute to cancer and discover new targets for future treatments.
Who could benefit from this research
Good fit: This foundational research is not currently recruiting patients, but future studies building on this knowledge may seek individuals with specific cancer types.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new treatments that specifically target these enzymes to fight cancer.
How similar studies have performed: This project proposes a novel strategy to overcome a significant challenge in identifying these enzyme interactions, building on existing knowledge of protein engineering and mass spectrometry.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Shah, Neel H — Columbia Univ New York Morningside
- Study coordinator: Shah, Neel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.