Understanding how certain enzymes affect skin barrier formation
Official title: Analytical approaches to fatty acid oxygenases and their lipid mediator products
Funded at Vanderbilt University · NIH-10765369 · Data updated 2026-11-12
This study is looking at how certain enzymes help create important fats that keep your skin healthy and protected, and it could help people with skin conditions like congenital ichthyosis understand their issues better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $396,250 |
| NIH project number | 1R35GM152031-01 |
| Project ID | NIH-10765369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital ichthyosis or other skin disorders related to lipid metabolism.
✕Less likely to help
Patients with skin conditions unrelated to lipid metabolism or those without significant skin barrier issues may not benefit from this research.
What this research studies
This research investigates the role of specific enzymes, known as lipoxygenases, in the production of lipid molecules that are crucial for maintaining the skin's barrier function. By analyzing how these enzymes interact with fatty acids and their oxidation products, the study aims to uncover the mechanisms that lead to the formation of a protective layer in the skin. Patients with conditions like congenital ichthyosis, which results in severe skin issues, may benefit from insights gained through this research. The approach includes advanced techniques such as recombinant enzyme studies and quantitative mass spectrometry to explore these biochemical pathways in detail.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for skin disorders that compromise the skin barrier.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism and its impact on skin health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Brash, Alan R. — Vanderbilt University
- Study coordinator: Brash, Alan R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.