Understanding how certain enzymes affect leukemia through chromatin regulation
Official title: Epigenetic mechanisms of regulation of histone lysine methyltransferases involved in leukemia
Funded at New York University School of Medicine · NIH-10912011 · Data updated 2026-11-12
This study is looking at how certain enzymes change proteins that help organize DNA in our cells, with the goal of finding new ways to treat leukemia, so patients can benefit from better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $452,033 |
| NIH project number | 5R01GM144547-02 |
| Project ID | NIH-10912011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with leukemia, particularly those whose condition may be influenced by the regulation of histone modifications.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by chromatin regulation mechanisms may not receive any benefit from this research.
What this research studies
This research investigates the role of specific enzymes that modify histones, which are proteins that help package DNA in cells. By examining how these modifications influence the structure of chromatin, the study aims to uncover mechanisms that could lead to better treatments for leukemia. The research focuses on the enzymes involved in methylation, particularly in the context of transcription and cell cycle control. Patients may benefit from insights gained about how these processes can be targeted for therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating leukemia by targeting the enzymes involved in chromatin regulation.
How similar studies have gone: Previous research has shown promising results in targeting chromatin-modifying enzymes for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Armache, Karim Jean — New York University School of Medicine
- Study coordinator: Armache, Karim Jean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.