Understanding how certain enzymes affect heart function and disease.
Regulation and Function of Cyclic Nucleotide Phosphodiesterase in Cardiac Biology and Disease
This study is looking at how certain enzymes in the heart help control important signals that affect heart function, with the goal of finding new ways to treat heart failure and other heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10810836 on NIH RePORTER |
What this research studies
This research investigates the role of cyclic nucleotide phosphodiesterases (PDEs) in heart biology and disease, particularly focusing on how they regulate important signaling molecules like cAMP and cGMP. By examining the expression and function of these enzymes, the research aims to uncover their contributions to heart failure and other cardiovascular conditions. The approach includes studying the mechanisms by which PDEs maintain the balance of these cyclic nucleotides, which are crucial for heart muscle contraction and relaxation. The findings could lead to new therapeutic strategies for managing heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with heart failure or other cardiovascular diseases.
Not a fit: Patients with non-cardiovascular conditions or those without heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for heart failure and improve heart function in affected patients.
How similar studies have performed: Previous research has shown promising results in targeting PDEs for neurological diseases, suggesting potential for success in cardiovascular applications as well.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yan, Chen — University of Rochester
- Study coordinator: Yan, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.