Understanding how certain enzymes affect cytomegalovirus infection
Role of Deubiquitinases in CMV Pathogenesis
This study is looking at how certain enzymes help the cytomegalovirus (CMV) avoid the immune system, which could lead to new treatments for people affected by this virus.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project ID | NIH-10730892 on NIH RePORTER |
What this research studies
This research investigates the role of deubiquitinases, which are enzymes that remove ubiquitin from proteins, in the infection process of cytomegalovirus (CMV). By studying how these enzymes influence the virus's ability to cause disease, the research aims to uncover the molecular mechanisms that allow CMV to evade the immune response. The approach involves examining the interactions between viral and host proteins during natural infections, which could lead to new insights into antiviral strategies. Patients may benefit from this research as it could inform the development of targeted antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults over 21 years old who are infected with cytomegalovirus or at risk of infection.
Not a fit: Patients who are not infected with cytomegalovirus or do not have a risk of infection may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral treatments that improve outcomes for patients infected with cytomegalovirus.
How similar studies have performed: Previous research has shown that targeting viral deubiquitinases can be effective in controlling viral infections, suggesting that this approach may yield promising results.
Where this research is happening
Auburn, UNITED STATES
- Auburn University at Auburn — Auburn, United States (Active)
Researchers
- Principal investigator: Upton, Jason W — Auburn University at Auburn
- Study coordinator: Upton, Jason W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.