Understanding how certain enzymes affect cancer and immune responses
Catalytic and Regulatory Mechanisms of Heme-based Dioxygenases
This study is looking at certain enzymes that help break down an important amino acid, L-tryptophan, to see how they affect the immune system and cancer growth, with the hope of finding new ways to improve treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11011812 on NIH RePORTER |
What this research studies
This research focuses on key enzymes called indoleamine 2,3-dioxygenases (IDO1, IDO2) and tryptophan dioxygenase (TDO), which play a vital role in breaking down the essential amino acid L-tryptophan. By studying these enzymes, the research aims to uncover how they influence immune responses and contribute to cancer progression. The approach involves detailed analysis of enzyme structures and their interactions with various molecules, which could lead to new therapeutic strategies. Patients may benefit from insights gained about how these enzymes can be targeted to improve cancer treatments and immune system function.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or immune-related disorders that may be influenced by the activity of these enzymes.
Not a fit: Patients with conditions unrelated to the kynurenine pathway or those not affected by immune modulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cancer treatment and improve immune responses in patients.
How similar studies have performed: Previous research has shown promising results in targeting similar enzymes for cancer therapy, indicating a potential for success in this area.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Yeh, Syun-Ru — Albert Einstein College of Medicine
- Study coordinator: Yeh, Syun-Ru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.