Understanding how certain enzymes affect calcium buildup in blood vessels
Cyclic nucleotide phosphodiesterase regulation in vascular calcification
This study is looking at how calcium builds up in blood vessels, especially in people with kidney disease, diabetes, and circulation problems, to find new ways to prevent or treat this issue and help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11090429 on NIH RePORTER |
What this research studies
This research investigates the process of arterial calcification, which is the buildup of calcium in blood vessels, particularly in patients with chronic kidney disease, diabetes, and peripheral artery disease. The study aims to identify molecular targets and develop therapies to prevent or treat this condition by focusing on the role of cyclic nucleotides and their regulating enzymes. By understanding how these enzymes function in the context of vascular calcification, the research seeks to uncover new treatment options that could improve cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with chronic kidney disease, diabetes, or peripheral artery disease who are at risk for arterial calcification.
Not a fit: Patients without cardiovascular conditions or those not at risk for arterial calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat arterial calcification, significantly improving cardiovascular health for affected patients.
How similar studies have performed: While the specific focus on phosphodiesterase regulation in arterial calcification is novel, similar approaches targeting cyclic nucleotides have shown promise in other areas of cardiovascular research.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Cai, Yujun — Yale University
- Study coordinator: Cai, Yujun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.