Understanding how certain enzymes activate cancer-causing chemicals
Expression, Regulation and Function of the SULT1C Carcinogen-Activating Enzymes
This research explores how specific enzymes in our bodies, especially during development, process chemicals that can lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11017847 on NIH RePORTER |
What this research studies
Our bodies have enzymes called SULTs that help process various compounds, including those that can cause cancer. This project aims to understand how these SULT enzymes work and how their activity is controlled, particularly during human development. We want to learn more about how these enzymes activate harmful chemicals and how their levels change before and after birth. By understanding these processes, we can better protect ourselves from environmental toxins.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit individuals concerned about environmental carcinogen exposure and cancer risk, particularly those exposed during early life.
Not a fit: Patients seeking immediate treatment options for existing conditions will not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how certain cancers develop and potentially inform strategies to prevent them, especially in vulnerable populations like developing fetuses.
How similar studies have performed: This research builds upon previous findings by the research group that first identified specific SULT enzyme expression patterns during human development, indicating a novel and ongoing line of inquiry.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Runge-Morris, Melissa a — Wayne State University
- Study coordinator: Runge-Morris, Melissa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.