Understanding how certain enzymes activate alkanes in the human gut
Official title: Active-site models unravel mechanism of enzymatic alkane activation
Funded at Texas State University · NIH-10893643 · Data updated 2026-11-12
This study is looking at how certain enzymes in our gut help break down compounds that are important for producing and using methane, which could help us find better ways to support gut health and manage methane-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas State University NIH-funded |
| Lab location | 1 site (San Marcos, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $187,983 |
| NIH project number | 5R16GM150472-02 |
| Project ID | NIH-10893643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal diseases or those interested in the role of gut microbiota in health.
✕Less likely to help
Patients without gastrointestinal issues or those not affected by methane production in the gut may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific enzymes in the human gut, particularly those produced by archaea, activate alkanes, which are important for methane production and oxidation. The project focuses on a key enzyme called methyl-coenzyme M reductase (MCR) and its interactions with nickel cofactors. By creating and studying small molecule models that mimic the active site of MCR, researchers aim to gain insights into how these enzymes break and form chemical bonds. This understanding could lead to advancements in managing gastrointestinal health and methane-related processes.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gut microbiota functions and potentially lead to new treatments for gastrointestinal diseases.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding enzyme mechanisms and their implications for health.
Where this research is happening
-
Texas State University
San Marcos, United States Active
Researchers
- Principal investigator: Schilter, David — Texas State University
- Study coordinator: Schilter, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.