Understanding how certain drugs inhibit HIV-1 reverse transcriptase
Probing Molecular Mechanisms of Allosteric Inhibition of HIV-1 Reverse Transcriptase
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-11007442
This study looks at how certain medications work to block an important enzyme that helps the HIV virus multiply, with the goal of finding better treatments for people living with HIV, especially those facing challenges with drug resistance.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11007442 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms by which drugs inhibit HIV-1 reverse transcriptase, an enzyme crucial for the virus's replication. It focuses on how different classes of reverse transcriptase inhibitors interact with the enzyme and each other, potentially leading to more effective treatments for HIV. The study employs biochemical techniques and advanced imaging methods to explore these interactions at a molecular level, aiming to uncover new strategies for combating drug resistance in HIV treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently undergoing antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective HIV treatments that reduce the risk of drug resistance.
How similar studies have performed: Previous research has shown promising results in understanding drug interactions with HIV-1 reverse transcriptase, indicating that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLLANDER, KLARISSA — YALE UNIVERSITY
- Study coordinator: HOLLANDER, KLARISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus