Understanding how certain drugs inhibit HIV-1 reverse transcriptase
Official title: Probing Molecular Mechanisms of Allosteric Inhibition of HIV-1 Reverse Transcriptase
Funded at Yale University · NIH-11007442 · Data updated 2026-11-12
This study looks at how certain medications work to block an important enzyme that helps the HIV virus multiply, with the goal of finding better treatments for people living with HIV, especially those facing challenges with drug resistance.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI186613-01 |
| Project ID | NIH-11007442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which drugs inhibit HIV-1 reverse transcriptase, an enzyme crucial for the virus's replication. It focuses on how different classes of reverse transcriptase inhibitors interact with the enzyme and each other, potentially leading to more effective treatments for HIV. The study employs biochemical techniques and advanced imaging methods to explore these interactions at a molecular level, aiming to uncover new strategies for combating drug resistance in HIV treatment.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective HIV treatments that reduce the risk of drug resistance.
How similar studies have gone: Previous research has shown promising results in understanding drug interactions with HIV-1 reverse transcriptase, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Hollander, Klarissa — Yale University
- Study coordinator: Hollander, Klarissa
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.