Understanding how certain drugs can selectively activate specific pathways in cell communication.
Molecular Mechanisms of G protein-coupled Receptor Biased Signaling
['FUNDING_OTHER'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11075823
This study is looking at how certain proteins in our cells help them communicate and respond to signals, with the goal of creating new medications that work better and have fewer side effects for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11075823 on ClinicalTrials.gov |
What this research studies
This research investigates G protein-coupled receptors (GPCRs), which play a crucial role in how cells communicate and respond to signals. By focusing on biased signaling, the project aims to develop drugs that can selectively activate beneficial pathways while minimizing side effects. The approach involves using advanced techniques to analyze how different ligands interact with GPCRs at a molecular level, which could lead to the creation of more effective and safer medications. Patients may benefit from new therapies that target specific conditions with fewer adverse effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that are currently treated with GPCR-targeting drugs and who experience side effects.
Not a fit: Patients who do not use GPCR-targeting medications or have conditions unrelated to GPCR signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of drugs that provide effective treatment with reduced side effects for various conditions.
How similar studies have performed: Other research has shown promise in exploiting biased signaling for drug development, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCORVY, JOHN D — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MCCORVY, JOHN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.