Understanding how certain drugs affect kidney cells
Mechanosensitive determinants of podocyte physiology
This study is looking at how certain medications can hurt kidney cells, especially the important podocytes, to help find ways to prevent kidney damage from these drugs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11058921 on NIH RePORTER |
What this research studies
This research investigates how specific drugs can harm kidney cells, particularly focusing on podocytes, which are crucial for kidney function. By analyzing data on drug-related kidney issues, the study aims to uncover mechanisms that lead to kidney damage caused by these drugs. The researchers will use advanced techniques, including imaging and molecular analysis, to explore how drug interactions affect the structure and function of podocytes. This work could provide insights into preventing kidney damage from medications.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are on medications known to potentially harm kidney function, particularly those experiencing proteinuria.
Not a fit: Patients who are not taking nephrotoxic medications or do not have kidney-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for protecting kidney health in patients taking certain medications.
How similar studies have performed: Previous research has shown promising results in understanding drug-induced kidney damage, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Azeloglu, Evren U. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Azeloglu, Evren U.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.