Understanding how certain drugs affect bacteria and contribute to antibiotic resistance
Mechanisms underlying bacterial sensitivity to host-targeted drugs
This study is looking at how certain medications that aren't antibiotics can affect the good bacteria in your gut and possibly lead to antibiotic resistance, helping us understand how these drugs work and how we can improve future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11089532 on NIH RePORTER |
What this research studies
This research investigates how host-targeted drugs, which are not typically classified as antibiotics, can impact the gut microbiome and contribute to antibiotic resistance. By examining the effects of these drugs on bacterial cells, the study aims to identify the mechanisms of bacterial toxicity and the pathways involved. The approach includes high-throughput screening to systematically classify these drugs and understand their potential to cause dysbiosis in the microbiome. This knowledge could lead to new insights into antibiotic development and resistance mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are currently taking host-targeted medications and may be at risk for antibiotic resistance.
Not a fit: Patients who are not on any medications that target the gut microbiome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics and strategies to combat antibiotic resistance.
How similar studies have performed: Previous research has shown that understanding the interactions between drugs and the microbiome can lead to significant advancements in antibiotic development.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Mitchell, Amir — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Mitchell, Amir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.