Understanding how certain DNA structures cause genetic instability
Mechanisms of Genome Instability Mediated by Simple DNA Repeats
['FUNDING_OTHER'] · TUFTS UNIVERSITY MEDFORD · NIH-11030222
This study is looking into how certain repeated DNA sequences can cause problems in our genes that might lead to inherited diseases and cancer, using both yeast and human cells to learn more about these changes and how they happen, which could help us find better ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY MEDFORD (nih funded) |
| Locations | 1 site (Boston, UNITED STATES) |
| Trial ID | NIH-11030222 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind genome instability caused by specific DNA repeats, which can lead to various hereditary diseases and cancers. The team uses advanced sequencing techniques to explore how these DNA structures expand and affect cellular processes. By studying both yeast and human cells, they aim to uncover the fundamental processes that lead to these genetic changes, which could have significant implications for understanding and treating related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary diseases linked to DNA repeat expansions, such as autism-fragile X syndrome or certain types of cancer.
Not a fit: Patients with conditions unrelated to DNA repeat expansions or those not affected by genetic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of hereditary diseases and cancers, potentially informing better treatment strategies.
How similar studies have performed: Other research has shown promising results in understanding DNA repeat expansions, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, UNITED STATES
- TUFTS UNIVERSITY MEDFORD — Boston, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIRKIN, SERGEI — TUFTS UNIVERSITY MEDFORD
- Study coordinator: MIRKIN, SERGEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism-fragile X (AFRAX) syndrome, Cancers, Candidate Disease Gene, degenerative diseases of motor and sensory neurons, Degenerative Neurologic Disorders