Understanding how certain DNA repair processes lead to genetic instability
Mechanistic insights into translesion synthesis-dependent genome instability
This study is looking into how certain processes in our cells can go wrong and lead to diseases like cancer and neurodegenerative disorders, focusing on a specific protein called REV1 that helps fix damaged DNA, with the hope of finding new ways to improve treatments for patients dealing with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10898893 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind genome instability, which is linked to various diseases such as cancer and neurodegenerative disorders. It focuses on the translesion synthesis (TLS) pathway, particularly the role of the REV1 polymerase, which helps bypass DNA damage and fill gaps in DNA replication. By exploring how REV1 influences cellular processes like autophagy and cell death, the research aims to uncover new therapeutic targets that could improve treatment outcomes for patients with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers, neurodegenerative disorders, or other conditions linked to DNA instability.
Not a fit: Patients with stable genetic conditions or those not affected by DNA damage-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or prevent diseases associated with DNA mutations.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Chatterjee, Nimrat — University of Vermont & St Agric College
- Study coordinator: Chatterjee, Nimrat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.