Understanding how certain DNA elements affect tissue regeneration
Official title: Transposon control as a checkpoint during regeneration
Funded at Cornell University · NIH-10938302 · Data updated 2026-11-12
This study is looking at how certain DNA pieces help zebrafish heal their tissues, especially in their eyes, to learn more about how we might improve healing in humans.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,892 |
| NIH project number | 5F32EY034778-02 |
| Project ID | NIH-10938302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve tissue damage or degeneration, particularly those interested in advancements in regenerative therapies.
✕Less likely to help
Patients with conditions unrelated to tissue regeneration or those who do not have access to advanced regenerative therapies may not benefit from this research.
What this research studies
This research investigates the role of transposable elements (TEs) in the regeneration of tissues, specifically using zebrafish as a model organism. By examining how these mobile DNA elements influence the regeneration process, the study aims to uncover the genetic and molecular mechanisms that enable successful tissue repair. The approach involves analyzing gene expression patterns during the regeneration of retinal neurons, with a focus on how controlling TEs may serve as a critical checkpoint for regeneration. This research could provide insights into enhancing regenerative medicine for humans by understanding the differences in regenerative abilities across species.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine, potentially improving healing processes in humans.
How similar studies have gone: Previous studies have shown that understanding the role of transposable elements in regeneration has been successful in other organisms, suggesting a promising avenue for this research.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Angileri, Krista Marie — Cornell University
- Study coordinator: Angileri, Krista Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.