Understanding how certain DNA elements affect aging and diseases
Biogenesis and function of retrotransposon-derived circular DNA
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11140308
This study is looking at special DNA pieces that can change our genes and how they might affect aging and diseases, with a focus on their ability to make circular DNA, to help us understand their role in our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11140308 on ClinicalTrials.gov |
What this research studies
This research investigates retrotransposons, which are DNA elements that can change the genetic information of their host. The team will explore how these elements replicate and their effects on aging and diseases, particularly focusing on their ability to create circular DNA. By using advanced biological tools and systems, the researchers aim to uncover the mechanisms behind the activation of retrotransposons and their impact on health. This could lead to new insights into how these elements contribute to both beneficial and harmful processes in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or degenerative neurological diseases.
Not a fit: Patients with stable, non-degenerative conditions or those not affected by aging-related processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for understanding and potentially treating age-related diseases and cancers.
How similar studies have performed: While the study of retrotransposons is relatively novel, preliminary findings suggest that understanding their role could lead to significant advancements in biomedical research.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, ZHAO — DUKE UNIVERSITY
- Study coordinator: ZHANG, ZHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers