Understanding how certain DNA-binding domains affect chromatin remodeling in cells
Official title: Defining the roles for the sequence-non-specific DNA-binding domains in mammalian SWI/SNF chromatin remodeling complex assembly and function
Funded at Harvard University · NIH-10901266 · Data updated 2026-11-12
This study is looking at how certain parts of a protein complex that helps control gene activity work together, especially in relation to human cancers and brain development issues, to better understand how changes in these proteins can lead to diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,656 |
| NIH project number | 1F31CA290929-01 |
| Project ID | NIH-10901266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with mutations in SWI/SNF complex genes, particularly those affected by specific cancers or neurodevelopmental disorders.
✕Less likely to help
Patients without mutations in the SWI/SNF complex genes or those not affected by related conditions may not benefit from this research.
What this research studies
This research investigates the roles of specific DNA-binding domains within the mammalian SWI/SNF chromatin remodeling complexes, which are crucial for regulating gene expression and chromatin accessibility. The study will explore how these domains contribute to the assembly and function of these complexes, particularly in the context of human cancers and neurodevelopmental disorders. By using advanced techniques to analyze these interactions in human cells, the research aims to uncover the mechanisms behind mutations that affect these complexes and their implications for disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of certain cancers and neurodevelopmental disorders, potentially guiding future therapeutic strategies.
How similar studies have gone: Previous research has shown that understanding chromatin remodeling complexes can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
Harvard University
Cambridge, United States Active
Researchers
- Principal investigator: Lieberman, Whitney Kate — Harvard University
- Study coordinator: Lieberman, Whitney Kate
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.