Understanding how certain currents affect motor neuron function
Physiological Function of Persistent Inward Currents in Motor Neurons
['FUNDING_R21'] · UNIVERSITY OF ARIZONA · NIH-10663030
This study is looking at how certain electrical currents in nerve cells that control muscles help them work properly, especially during movement, and it aims to find out if these currents are always active or only when we're under stress, which could help us understand more about muscle control and related health issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10663030 on ClinicalTrials.gov |
What this research studies
This research investigates the role of persistent inward currents (PICs) in motor neurons, which are crucial for muscle contraction. By using an animal model, the study aims to determine how these currents influence the relationship between synaptic input and the firing rate of motor neurons during voluntary muscle activity. The research will explore whether PICs are active during normal motor function or only under specific conditions like stress. This could provide insights into how motor neuron activity is regulated and its implications for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with motor neuron diseases or related neurological disorders.
Not a fit: Patients with non-neurological conditions or those not experiencing motor function impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions affecting motor function, such as ALS and Alzheimer's disease.
How similar studies have performed: While the specific focus on persistent inward currents in motor neurons is relatively novel, similar research has shown promise in understanding neuronal function and its implications for various neurological conditions.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUGLEVAND, ANDREW J — UNIVERSITY OF ARIZONA
- Study coordinator: FUGLEVAND, ANDREW J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease