Understanding how certain colon cells affect gut inflammation
Activation of deep crypt secretory cells in colonic inflammation
['FUNDING_R01'] · CHILDREN'S HOSPITAL OF LOS ANGELES · NIH-11182711
This project aims to understand how special cells in the colon, called deep crypt secretory cells, respond to inflammation and help the gut heal, especially for people with conditions like inflammatory bowel disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSPITAL OF LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11182711 on ClinicalTrials.gov |
What this research studies
Our colon lining is crucial for health, but we don't fully understand how specific cells contribute to its well-being or disease. This project focuses on deep crypt secretory (DCS) cells, which are found at the base of the colon and play a role in immunity and healing. We believe these cells become "activated" during inflammation, changing how they protect the gut. By learning more about how DCS cells work and what happens when they don't function properly, we hope to find new ways to help the colon recover from inflammation.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes and potential future treatments for inflammatory bowel disease and other colonic inflammatory conditions.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target specific colon cells to reduce inflammation and promote healing for conditions like inflammatory bowel disease.
How similar studies have performed: This project explores a novel paradigm of DCS cell activation, building on recent preliminary data, suggesting it's a relatively new area of focus.
Where this research is happening
LOS ANGELES, UNITED STATES
- CHILDREN'S HOSPITAL OF LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUMACHER, MICHAEL ANDREW — CHILDREN'S HOSPITAL OF LOS ANGELES
- Study coordinator: SCHUMACHER, MICHAEL ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.