Understanding how certain chromosome changes affect kidney cancer cell behavior
Convergent Drivers of Tumor Evolution at the Mitotic Spindle
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10867377
This study is looking at how certain changes in the genes of clear cell kidney cancer cells affect how they grow and divide, with the hope of finding new ways to treat the cancer more effectively for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10867377 on ClinicalTrials.gov |
What this research studies
This research investigates clear cell renal cell carcinoma (ccRCC), a type of kidney cancer characterized by specific chromosome abnormalities. The study focuses on how these abnormalities influence the behavior of cancer cells during cell division, particularly looking at the roles of certain proteins and enzymes that help maintain genomic stability. By examining the interactions between chromatin remodelers and the mitotic spindle, the research aims to uncover new insights into the mechanisms that drive tumor evolution and stability. Patients may benefit from a better understanding of their cancer's biology, potentially leading to more targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with clear cell renal cell carcinoma.
Not a fit: Patients with other types of kidney cancer or those without chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with clear cell renal cell carcinoma.
How similar studies have performed: Other research has shown promising results in understanding chromosomal abnormalities in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MASON, FRANK M — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: MASON, FRANK M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.