Understanding how certain chemicals affect type 2 diabetes
Perfluoroalkyl substances and incident type 2 diabetes in a US population: A metabolome-genome investigation
This project looks at how common chemicals called PFAS might contribute to developing type 2 diabetes in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11142623 on NIH RePORTER |
What this research studies
We know that type 2 diabetes is becoming more common, and we want to understand all the reasons why. This project explores whether everyday chemicals called PFAS, which are found almost everywhere, might play a role in causing type 2 diabetes. We are looking at blood samples collected before people developed diabetes to see if PFAS levels and genetic factors work together to increase risk. By examining changes in metabolism, we hope to find early signs of diabetes linked to these chemical exposures.
Who could benefit from this research
Good fit: This project focuses on adults in the US population who have developed type 2 diabetes or are at risk, using existing blood samples.
Not a fit: Patients not interested in the environmental factors contributing to type 2 diabetes may not find direct benefit from this specific research.
Why it matters
Potential benefit: This work could help us better understand the causes of type 2 diabetes, potentially leading to new ways to prevent or detect it earlier.
How similar studies have performed: While some evidence suggests a link between PFAS and diabetes, this project uses advanced methods to explore these connections more thoroughly than previous, smaller studies.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Valvi, Damaskini — Icahn School of Medicine at Mount Sinai
- Study coordinator: Valvi, Damaskini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.