Understanding how certain changes in colon cells lead to cancer
Computational approaches to the mechanistic elucidation of the serrated pathway of human colon carcinogenesis
This study is looking into how certain changes in colon cells can lead to colon cancer, especially in cases that are not well understood, and it's being led by Dr. Marmar Moussa, who is training to better understand cancer genetics and biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma NIH-funded |
| Lab location | 1 site (Norman, United States) |
| Project ID | NIH-10892048 on NIH RePORTER |
What this research studies
This research focuses on developing advanced computational methods to explore the mechanisms behind a specific pathway that leads to colon cancer, known as the serrated pathway. The principal investigator, Dr. Marmar Moussa, is gaining training in cancer genomics and biology to lead this important work. By analyzing genetic and epigenetic changes in colon cells, the research aims to uncover how these changes contribute to the development of colorectal cancer, particularly in cases that are less understood. This work is crucial as colorectal cancer remains a leading cause of cancer-related deaths in the U.S.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for colorectal cancer or those with a history of serrated lesions.
Not a fit: Patients with colorectal cancer that does not involve the serrated pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for colorectal cancer.
How similar studies have performed: Other research has shown promise in understanding cancer pathways, but this specific approach to the serrated pathway is relatively novel.
Where this research is happening
Norman, United States
- University of Oklahoma — Norman, United States (Active)
Researchers
- Principal investigator: Moussa, Marmar — University of Oklahoma
- Study coordinator: Moussa, Marmar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.