Understanding how certain cellular structures form and function
Mechanisms of Assembly and Functional Regulation in Non-canonical Biomolecular Condensates
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10898721
This study is looking at tiny structures in our cells that help them work properly, and it's for anyone interested in how these structures can sometimes go wrong and lead to diseases; researchers are using cool tools to see how proteins behave in these structures to learn more about how our cells communicate.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10898721 on ClinicalTrials.gov |
What this research studies
This research investigates biomolecular condensates, which are structures within cells that self-assemble without membranes. These condensates play a crucial role in normal cellular functions, and their misregulation can lead to various diseases. The research employs advanced techniques like CRISPR imaging and optogenetics to explore how proteins interact within these condensates and how this affects cell signaling. By identifying new motifs and principles governing these structures, the research aims to enhance our understanding of cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diseases linked to cellular misregulation, such as certain cancers or neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to cellular processes or those not involving biomolecular condensates may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into disease mechanisms and potential therapeutic targets for conditions related to cellular dysfunction.
How similar studies have performed: While the study of biomolecular condensates is a growing field, the specific approaches and techniques proposed in this research are relatively novel and have not been extensively tested.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUAN, JUAN — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: GUAN, JUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.