Understanding how certain cellular changes in breast cancer promote metastasis
Translation regulation of the mesenchymal transition by the rRNA and mRNA m6A axis
This study is looking at how certain changes in breast cancer cells help them spread more easily, with the hope of finding new ways to prevent or treat advanced breast cancer that has spread.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11091559 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the epithelial-to-mesenchymal transition (EMT) in breast cancer, a process that allows cancer cells to become more invasive. By studying how specific proteins and modifications affect the translation of RNA, the research aims to uncover new insights into how breast cancer cells spread. The approach involves analyzing the interactions between various proteins and RNA modifications that drive this transition, which could lead to new therapeutic targets. Patients may benefit from a better understanding of how to prevent or treat metastatic breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with metastatic breast cancer or those at high risk for developing metastasis.
Not a fit: Patients with early-stage breast cancer that has not metastasized may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metastatic breast cancer.
How similar studies have performed: Other research has shown promising results in targeting the EMT process in cancer, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Vincent, Clara Theresa — New York University School of Medicine
- Study coordinator: Vincent, Clara Theresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.