Understanding how certain cells turn into rhabdomyosarcoma, a type of cancer.
Official title: Determining the Mechanism of Rhabdomyosarcoma Transformation from a Non-Myogenic Cell of Origin
Funded at St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC · NIH-11071727 · Data updated 2026-11-12
This study is looking into how certain cells that aren't muscle cells can turn into rhabdomyosarcoma, a type of aggressive cancer that affects kids, to help us understand why this happens and find better ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 13, 2025 |
| Project end | May 12, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,538 |
| NIH project number | 1F31CA290924-01A1 |
| Project ID | NIH-11071727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with rhabdomyosarcoma, particularly those with the fusion-negative subtype.
✕Less likely to help
Patients with other types of cancer or those who do not have rhabdomyosarcoma may not benefit from this research.
What this research studies
This research investigates the transformation of non-myogenic cells into rhabdomyosarcoma (RMS), a common and aggressive pediatric soft tissue cancer. The study aims to uncover the mechanisms behind this transformation, focusing on the genetic factors that influence cell fate. By examining the role of specific lineage specification factors, the research seeks to provide insights into how RMS develops in tissues that lack skeletal muscle. This could lead to a better understanding of the disease and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for rhabdomyosarcoma, improving survival rates for affected patients.
How similar studies have gone: While there has been significant research into rhabdomyosarcoma, this specific investigation into the transformation from non-myogenic cells is novel and has not been extensively studied.
Where this research is happening
-
St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC
Memphis, United States Active
Researchers
- Principal investigator: Adkins, Grace Elizabeth — St. Jude Children's Research Hospital Graduate School of Biomedical Sciences, LLC
- Study coordinator: Adkins, Grace Elizabeth
Related research
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-
Epitranscriptomic Crosstalk in Alveolar Rhabdomyosarcoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.