Understanding how certain cells turn into melanoma using zebrafish
Defining Transcriptional Regulators of Melanoma Initiation using Zebrafish
This study is looking at how melanoma starts by watching certain cells change into cancerous ones in zebrafish, which could help doctors find and treat melanoma earlier for better results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10691465 on NIH RePORTER |
What this research studies
This research investigates the early stages of melanoma development by studying specific cells that may transform into cancerous cells. Using a zebrafish model, researchers have developed a method to visualize these early changes in real-time, focusing on the role of a particular genetic mutation found in many melanoma cases. By identifying the mechanisms that lead to this transformation, the research aims to improve early detection and treatment strategies for melanoma, potentially leading to better outcomes for patients. The study emphasizes the importance of understanding the cellular environment and genetic factors that contribute to cancer initiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of skin lesions or moles that may carry genetic mutations associated with melanoma.
Not a fit: Patients without any skin lesions or those who do not have a family history of melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective treatments for melanoma, improving patient survival rates.
How similar studies have performed: Other research has shown promise in using animal models to study cancer initiation, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Kaufman, Charles Kore — Washington University
- Study coordinator: Kaufman, Charles Kore
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.