Understanding how certain cells organize their microtubules
Patterning acentrosomal microtubule arrays
This study is looking at how certain tiny structures in cells, called microtubules, are organized in different types of cells like nerve and reproductive cells, using a small worm as a model, to better understand how these structures help cells do their jobs and develop properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11011739 on NIH RePORTER |
What this research studies
This research investigates the organization of acentrosomal microtubule arrays in various differentiated cells, such as neurons and germline cells, using the model organism C. elegans. The team employs advanced imaging techniques and algorithms to analyze microtubule structures and their role in cellular functions like cargo transport. By identifying novel microtubule regulators and their mechanisms, the research aims to uncover how these structures contribute to cellular differentiation and function. This work could provide insights into the fundamental processes that govern cell behavior and development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions linked to cellular differentiation and microtubule dysfunction.
Not a fit: Patients with conditions unrelated to cellular differentiation or microtubule function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cellular dysfunction and differentiation.
How similar studies have performed: Other research has shown success in understanding microtubule organization and its implications in cellular processes, indicating that this approach builds on established findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yogev, Shaul — Yale University
- Study coordinator: Yogev, Shaul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.