Understanding how certain cells multiply and contribute to cancer
Mechanisms of cell proliferation in whole-genome doubled cells
['FUNDING_R01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-11078848
This study is looking at how certain cells with extra DNA can develop and survive, which is important for understanding diseases like cancer, especially as we age, and it aims to find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11078848 on ClinicalTrials.gov |
What this research studies
This research investigates how whole-genome doubling (WGD) events lead to the formation of polyploid cells, which are linked to various human diseases, particularly cancer. By combining computational analysis, cell biology techniques, and animal models, the researchers aim to uncover the mechanisms that allow these cells to thrive despite having doubled DNA content. The study will explore how aging may influence the frequency of WGD and identify specific genetic adaptations that these cells acquire, which could lead to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with solid tumors that may have undergone whole-genome doubling.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not exhibit whole-genome doubling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with whole-genome doubling.
How similar studies have performed: Other research has shown promising results in understanding the role of genetic adaptations in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GANEM, NEIL J. — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: GANEM, NEIL J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell