Understanding how certain cells interact in rheumatoid arthritis
Synoviocyte endothelial cell cross talk in rheumatoid arthritis
This study is looking at how certain cells in the joints of people with rheumatoid arthritis interact with blood vessel cells, hoping to find new ways to reduce inflammation and joint damage without using strong immune-suppressing treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11120191 on NIH RePORTER |
What this research studies
This research investigates the interactions between synoviocyte and endothelial cells in patients with rheumatoid arthritis (RA). By utilizing genomic approaches, the study aims to uncover the mechanisms behind the migration of specific cells from the synovium into the bloodstream and how this affects inflammation and joint damage. The researchers have developed an in vitro system to analyze these cell interactions and have identified a gene that may control this process. This could lead to more targeted therapies that are less immunosuppressive for RA patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing ongoing symptoms despite current treatments.
Not a fit: Patients with rheumatoid arthritis who are in remission or those with other types of arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and tailored treatments for rheumatoid arthritis that minimize immunosuppression.
How similar studies have performed: Other research has shown promise in understanding cell interactions in rheumatoid arthritis, but this specific approach focusing on synoviocyte and endothelial cell interactions is relatively novel.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bottini, Nunzio — Cedars-Sinai Medical Center
- Study coordinator: Bottini, Nunzio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.