Understanding how certain cells in the placenta develop during early pregnancy.
Official title: Early Events in Extravillous Trophoblast Cell Differentiation
Funded at University of Kansas Medical Center · NIH-10950034 · Data updated 2026-11-12
This study is looking at how certain cells in the placenta develop, which is important for a healthy pregnancy, and it aims to find out what helps or hinders this process, especially to better understand issues like preeclampsia and early pregnancy loss.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $130,680 |
| NIH project number | 1K99HD115834-01 |
| Project ID | NIH-10950034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing complications during early pregnancy.
✕Less likely to help
Patients who are not pregnant or those with no history of placental complications may not benefit from this research.
What this research studies
This research investigates the differentiation of extravillous trophoblast (EVT) cells, which are crucial for proper placental function and fetal blood supply during early pregnancy. By utilizing advanced techniques like single cell RNA sequencing, the study aims to identify key regulatory mechanisms and factors, such as the CCAAT/enhancer-binding protein beta (CEBPB), that influence the development of these cells. Understanding these processes could help address complications that arise from impaired EVT cell development, such as preeclampsia and early pregnancy loss.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and managing pregnancy complications related to placental dysfunction.
How similar studies have gone: Previous research has shown success in understanding trophoblast cell differentiation, but this specific focus on CEBPB and its regulatory role is relatively novel.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Moreno, Ayelen — University of Kansas Medical Center
- Study coordinator: Moreno, Ayelen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.