Understanding how certain cells in the lungs help with tissue organization and cell development
Official title: Role of alveolar fibroblasts in extracellular matrix organization and alveolar type 1 cell differentiation
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10912833 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs help build and repair lung tissue, with the goal of finding new treatments for conditions like Bronchopulmonary Dysplasia in premature babies and improving lung healing in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $768,391 |
| NIH project number | 5R01HL167030-02 |
| Project ID | NIH-10912833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include premature infants at risk for Bronchopulmonary Dysplasia and adults with lung regeneration needs.
✕Less likely to help
Patients with stable lung conditions who do not require intervention or have no history of lung injury may not benefit from this research.
What this research studies
This research investigates the role of alveolar fibroblasts in the lungs, focusing on how they contribute to the organization of the extracellular matrix and the differentiation of alveolar type 1 cells. By examining the molecular mechanisms that regulate these processes, the research aims to develop therapies for conditions like Bronchopulmonary Dysplasia (BPD) in premature infants and to enhance lung regeneration in adults. The study utilizes advanced techniques to analyze changes in fibroblast function during lung development and repair, providing insights that could lead to innovative treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung health and regeneration for patients with BPD and other lung conditions.
How similar studies have gone: Other research has shown promising results in understanding fibroblast functions in lung development, indicating that this approach has potential for success.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Perl, Anne-Karina Theresia — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Perl, Anne-Karina Theresia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.