Understanding how certain cells in the lungs control fluid balance for better respiratory health
Official title: Receptor-mediated Control of Pulmonary Ionocytes
Funded at University of Iowa · NIH-11049908 · Data updated 2026-11-12
This study is looking at how certain lung cells help keep the airways moist and healthy, focusing on a molecule called PGE2, to find new treatments for breathing problems like bronchitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | March 15, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $551,863 |
| NIH project number | 1R01HL173260-01A1 |
| Project ID | NIH-11049908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from airway diseases such as bronchitis or other conditions affecting lung function.
✕Less likely to help
Patients with non-respiratory conditions or those without airway diseases may not receive any benefit from this research.
What this research studies
This research investigates how specific lung cells, called ionocytes and secretory cells, manage the balance of liquid in the airways, which is vital for respiratory health. It focuses on the role of a molecule called PGE2 in regulating the absorption and secretion of airway surface liquid. By exploring how PGE2 affects these cells and their functions, the research aims to uncover new ways to treat pulmonary diseases. Patients may benefit from insights that could lead to novel therapies for conditions like bronchitis and other airway diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve airway health and manage respiratory diseases more effectively.
How similar studies have gone: Other research has shown promise in understanding the roles of ionocytes and secretory cells in lung health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Thornell, Ian M — University of Iowa
- Study coordinator: Thornell, Ian M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.