Understanding how certain cells in the gut regulate appetite and insulin secretion
Official title: Mechanisms mediating human enteroendocrine cell differentiation and function
Funded at Boston Children's Hospital · NIH-11094921 · Data updated 2026-11-12
This study is looking at how certain cells in your gut that help control hunger and insulin work, to find new ways to help people with obesity and type 2 diabetes feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $167,940 |
| NIH project number | 5K08DK134885-03 |
| Project ID | NIH-11094921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or type 2 diabetes who are interested in new treatment options.
✕Less likely to help
Patients with conditions unrelated to appetite regulation or insulin secretion may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the differentiation and function of enteroendocrine cells (EECs), which play a crucial role in regulating appetite and insulin secretion. By examining both intrinsic factors, like specific proteins that influence cell growth, and extrinsic factors, such as nutrients and hormones, the study aims to uncover how these elements interact in healthy and diseased states. The goal is to identify potential therapeutic targets that could help manage obesity and type 2 diabetes by modulating EEC activity.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively regulate appetite and improve insulin secretion, benefiting patients with obesity and type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of enteroendocrine cells in metabolic regulation, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Zeve, Daniel Richard — Boston Children's Hospital
- Study coordinator: Zeve, Daniel Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.