Understanding how certain cells in the ear help with hearing after damage.
Mechanisms of PCP signaling in axon guidance and cochlear innervation
This study is looking at how we can help important nerve cells in the ear reconnect with the tiny hair cells that help us hear after they've been damaged by loud noises, with the hope of finding new ways to treat hearing loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10867423 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which spiral ganglion neurons, which are crucial for hearing, can be coaxed to reconnect with hair cells in the cochlea after damage from acoustic trauma. The study focuses on understanding the developmental processes that allow these neurons to properly innervate hair cells, which is essential for restoring hearing. By exploring specific signaling pathways involved in this process, the research aims to identify potential therapeutic strategies for repairing hearing loss. Patients may benefit from insights that could lead to new treatments for deafness caused by noise exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced hearing loss due to acoustic trauma.
Not a fit: Patients with hearing loss from non-acoustic causes, such as genetic factors or aging, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that restore hearing in patients suffering from acoustic trauma.
How similar studies have performed: Previous research has shown promise in understanding cochlear innervation, suggesting that this approach could lead to significant advancements in hearing restoration.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Park, Sung Jin — University of Utah
- Study coordinator: Park, Sung Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.