Understanding how certain cells in the colon affect colitis
The role and regulation of deep crypt secretory cells in colitis
This study is looking at special cells in the colon that might affect conditions like colitis, with the hope of understanding how they work and how they could help develop new treatments for inflammatory bowel disease (IBD).
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10895525 on NIH RePORTER |
What this research studies
This research investigates deep crypt secretory (DCS) cells in the colon, which play a role in colitis but are not well understood. The study aims to identify how these cells differentiate and produce proteins that influence the immune response and epithelial functions. By using both mouse models and advanced techniques, the research will explore the impact of DCS cells on colonic health and disease severity. Patients may benefit from insights that could lead to new treatments for inflammatory bowel disease (IBD).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel disease, particularly those with colitis.
Not a fit: Patients with non-inflammatory bowel conditions or those without any gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating inflammatory bowel disease.
How similar studies have performed: While the specific focus on DCS cells is novel, similar research has shown promise in understanding the role of secretory cells in gastrointestinal diseases.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Schumacher, Michael Andrew — Children's Hospital of Los Angeles
- Study coordinator: Schumacher, Michael Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.