Understanding how certain cells in the brain develop to help repair nerve damage in multiple sclerosis.
Official title: Transcriptional regulation of oligodendroglial differentiation
Funded at Stanford University · NIH-10984598 · Data updated 2026-11-12
This study is looking at how certain cells in the brain that help repair nerve coverings might not work properly in multiple sclerosis, with the hope of finding new ways to help improve myelin repair and support better nerve function for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,685 |
| NIH project number | 1K99NS135117-01A1 |
| Project ID | NIH-10984598 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing symptoms related to nerve damage.
✕Less likely to help
Patients with other neurological disorders unrelated to myelin damage may not receive benefits from this research.
What this research studies
This research investigates the mechanisms that control the differentiation of oligodendrocyte precursor cells (OPCs), which are crucial for producing myelin, the protective sheath around nerves. By exploring the role of transcription factors and circadian rhythms in OPC behavior, the study aims to uncover why remyelination fails in multiple sclerosis (MS). Patients may benefit from insights that could lead to new therapies aimed at enhancing myelin repair and improving neurological function. The research employs advanced techniques, including CRISPR-based screens, to analyze gene expression and cell behavior in the context of MS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance myelin repair in patients with multiple sclerosis, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in neural repair, suggesting that this approach could yield significant insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Rojo Capitanio, Daniela — Stanford University
- Study coordinator: Rojo Capitanio, Daniela
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to predict CAR-T patient response and guide safer, smarter cell design
A Stanford team is building AI tools that use patient and CAR-T cell data to predict how well a CAR-T therapy will work and what design changes might boost effectiveness and safety for people with cancer.
-
Community-driven model to reduce overdose deaths through smarter resource use
A Stanford-led project uses a data-driven model to help counties pick the best ways to prevent opioid and stimulant overdoses and save lives.
-
Center for Dissemination and Implementation at Stanford: Research Core
A Stanford-based program is advancing how evidence-based addiction treatments are implemented across settings to help people with substance use disorders receive better care.
-
Center for Dissemination and Implementation At Stanford (C-DIAS)
A center-based program at Stanford aims to speed people who need addiction treatments to get evidence-based care.
-
Mitochondrial structure and neuron health in Alzheimer's and ALS
This grant studies how mitochondrial cristae structure in neurons is controlled and how its disruption may contribute to diseases like Alzheimer's and ALS.
-
Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.