Understanding how certain cells in skin tumors affect immune response in mycosis fungoides

Who could benefit from this research

What this research studies

This research investigates the role of cancer-associated fibroblasts (CAFs) in the skin of patients with early-stage mycosis fungoides, a type of skin lymphoma. By using advanced techniques like single-cell RNA sequencing and spatial RNA transcriptomics, the study aims to identify different subtypes of CAFs and their locations within the tumor microenvironment. This approach will help uncover how these cells contribute to immune evasion and disease progression, particularly across diverse patient demographics. The findings could lead to better understanding and potential new treatments for mycosis fungoides.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Johnson, Courtney Michele — Johns Hopkins University
• Study coordinator: Johnson, Courtney Michele

Related research

Other NIH-funded projects on the same topics.

• Understanding how skin cancer-associated fibroblasts affect immune detection in early mycosis fungoides

  This grant investigates how certain skin cells in early mycosis fungoides might help the cancer hide from the immune system, with findings aiming to improve future patient care.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11617656

• Microbiome clues to better radiation response in a rare skin lymphoma

  Researchers are studying skin lymphoma CTCL to see how the gut and skin bacteria might influence how well radiation therapy works for patients.

  NIH research Emory University · Atlanta, United States · NIH-11391466

• Identifying a new marker for early diagnosis of a skin cancer called mycosis fungoides

  This study is looking at a specific marker in the skin cells of people with early-stage mycosis fungoides, a type of skin cancer, to help doctors find it more easily and provide better treatment for patients.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11009055

• Visible-light activated hypericin ointment for mycosis fungoides

  A topical hypericin ointment activated by safe visible light aims to treat skin lesions in people with mycosis fungoides.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11000756

• Poteligeo (mogamulizumab) for adults with mycosis fungoides or Sézary syndrome

  This project will try Poteligeo (mogamulizumab) in adults with mycosis fungoides or Sézary syndrome who have had at least one prior systemic therapy to see how safe and effective it is in routine care in Korea.

  Recruiting at 5 sites Kyowa Kirin Co., Ltd. · Busan, Busan Metropolitan City and 5 other locations · NCT07132567

• Golidocitnib treatment for relapsed indolent T/NK-cell lymphomas

  This study is testing if a new oral medication called Golidocitnib can help people with relapsed indolent T/NK-cell lymphomas feel better after other treatments haven't worked.

  Recruiting Phase 2 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality and 1 other locations · NCT06716658

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.