Understanding how certain cells in skin tumors affect immune response in mycosis fungoides
Investigating the Role of Cancer-Associated Fibroblasts in Immunodetection of Mycosis Fungoides
This study is looking at how certain cells in the skin, called cancer-associated fibroblasts, behave in patients with early-stage mycosis fungoides, a type of skin lymphoma, to help us understand how they might affect the disease and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10948591 on NIH RePORTER |
What this research studies
This research investigates the role of cancer-associated fibroblasts (CAFs) in the skin of patients with early-stage mycosis fungoides, a type of skin lymphoma. By using advanced techniques like single-cell RNA sequencing and spatial RNA transcriptomics, the study aims to identify different subtypes of CAFs and their locations within the tumor microenvironment. This approach will help uncover how these cells contribute to immune evasion and disease progression, particularly across diverse patient demographics. The findings could lead to better understanding and potential new treatments for mycosis fungoides.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage mycosis fungoides, particularly those from diverse demographic backgrounds.
Not a fit: Patients with advanced-stage mycosis fungoides or other types of skin cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for detecting and treating mycosis fungoides by targeting the mechanisms of immune evasion.
How similar studies have performed: Previous research has shown promising results in understanding tumor microenvironments and immune interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Johnson, Courtney Michele — Johns Hopkins University
- Study coordinator: Johnson, Courtney Michele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.