Understanding how certain cells help the uterus heal and regenerate
Functional characterization of mesenchymal-epithelial transition (MET)-derived cells in normal endometrial regeneration
This study is looking at how certain cells in the uterus change to help repair its lining, which is important for women’s reproductive health, and it hopes to find new ways to treat issues like Asherman’s Syndrome and infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11088301 on NIH RePORTER |
What this research studies
This research investigates the process of mesenchymal-epithelial transition (MET), which is crucial for the regeneration of the endometrium, the lining of the uterus. By studying how mesenchymal cells transform into epithelial cells, the research aims to uncover the mechanisms behind normal endometrial repair and how disruptions in this process can lead to conditions like Asherman’s Syndrome and infertility. The approach includes experiments that compare the roles of endometrial-derived and bone marrow-derived cells in this regeneration process. Patients may benefit from insights that could lead to new treatments for reproductive health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing reproductive health issues, particularly those with conditions like Asherman’s Syndrome or infertility.
Not a fit: Patients who do not have reproductive health issues or those outside the reproductive age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women suffering from infertility and other reproductive health disorders.
How similar studies have performed: While the concept of MET has been explored in other contexts, this specific investigation into endometrial regeneration is relatively novel and has not been extensively tested.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Patterson, Amanda — University of Missouri-Columbia
- Study coordinator: Patterson, Amanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.