Understanding how certain cells help repair lung damage after injury
p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11131287
This research looks at how specific cells in the lung, which increase with age, help repair lung tissue after an injury.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11131287 on ClinicalTrials.gov |
What this research studies
As we get older, certain cells in our body, called senescent cells, build up in tissues, including the lungs. These cells, marked by a protein called p16INK4a, stop dividing but can influence their surroundings. While removing these cells might slow down aging, it can also negatively affect how wounds heal. This project uses a special mouse model to understand how these p16INK4a+ cells, particularly fibroblasts in the lung, help the lung repair itself after injury. We want to learn if these cells can promote the growth of new lung lining cells.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals interested in the biology of aging and lung repair, particularly those who experience lung injuries.
Not a fit: Patients seeking immediate treatment options for lung conditions would not directly benefit from this basic science research.
Why it matters
Potential benefit: This work could lead to new ways to improve lung repair and recovery for people who have experienced lung injuries, especially as they age.
How similar studies have performed: While the role of senescent cells in aging is known, their specific and potentially contradictory roles in wound healing and regeneration are still being explored, making this a novel area of focus.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REYES DE BARBOZA, NABORA SOLEDAD — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: REYES DE BARBOZA, NABORA SOLEDAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.