Understanding how certain cells develop to support pregnancy
Pathways Affecting Trophoblast Development
This study is looking at how certain cells in the uterus help get it ready for a healthy pregnancy, and it aims to find ways to improve pregnancy success by understanding how these cells work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11114056 on NIH RePORTER |
What this research studies
This research investigates the role of specific cell types, known as trophoblasts, in preparing the uterus for a successful pregnancy. It focuses on how these cells change and invade the uterine environment, which is crucial for implantation. The study examines the regulatory networks that control the development of these cells, using both human and rat models. By analyzing patient-specific trophoblast stem cells, the research aims to uncover the mechanisms that could lead to improved pregnancy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing difficulties with pregnancy or those at risk for pregnancy-related complications.
Not a fit: Patients who are not planning to conceive or who have no history of pregnancy complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing pregnancy complications and improving fertility.
How similar studies have performed: Other research has shown promise in understanding trophoblast development, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Soares, Michael J — University of Kansas Medical Center
- Study coordinator: Soares, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.