Understanding how certain cells develop to support pregnancy
Official title: Pathways Affecting Trophoblast Development
Funded at University of Kansas Medical Center · NIH-11114056 · Data updated 2026-11-12
This study is looking at how certain cells in the uterus help get it ready for a healthy pregnancy, and it aims to find ways to improve pregnancy success by understanding how these cells work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 13, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $620,463 |
| NIH project number | 5R01HD112559-02 |
| Project ID | NIH-11114056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing difficulties with pregnancy or those at risk for pregnancy-related complications.
✕Less likely to help
Patients who are not planning to conceive or who have no history of pregnancy complications may not benefit from this research.
What this research studies
This research investigates the role of specific cell types, known as trophoblasts, in preparing the uterus for a successful pregnancy. It focuses on how these cells change and invade the uterine environment, which is crucial for implantation. The study examines the regulatory networks that control the development of these cells, using both human and rat models. By analyzing patient-specific trophoblast stem cells, the research aims to uncover the mechanisms that could lead to improved pregnancy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing pregnancy complications and improving fertility.
How similar studies have gone: Other research has shown promise in understanding trophoblast development, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Soares, Michael J — University of Kansas Medical Center
- Study coordinator: Soares, Michael J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.