Understanding how certain cells develop into facial structures
Molecular Regulatory Mechanism of Cranial Neural Crest Development
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10744204
This study is looking at how certain cells help shape our faces and how problems with these cells can lead to birth defects like cleft lip and palate, with the hope of finding better treatments for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10744204 on ClinicalTrials.gov |
What this research studies
This research investigates the development of cranial neural crest (CNC) cells, which are crucial for forming various facial structures such as bones and cartilage. By examining the molecular mechanisms that regulate CNC development, particularly the interactions between Hippo and Wnt signaling pathways, the research aims to uncover how abnormalities in these processes can lead to common birth defects like cleft lip and palate. The study employs advanced biological assays to analyze cell migration and differentiation, providing insights that could lead to improved treatments for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital craniofacial abnormalities or those at risk of developing such conditions.
Not a fit: Patients with non-congenital facial abnormalities or those unrelated to cranial neural crest development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential therapies for congenital facial defects.
How similar studies have performed: Previous research has shown promising results in understanding signaling pathways in development, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, JUN — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: WANG, JUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.